北海道大学病院呼吸器外科では臨床研究や基礎研究に力を注いています。これらの研究結果に基づく新しい治療法の開発によって、治療成績の向上を目指しています。

• • 局所進行非小細胞肺癌に対する同時化学放射線療法後切除の第二相試験(自008-0019終了）

  • 胸膜腫瘍および胸腺腫瘍における免疫組織学的手法を用いた診断・予後予測マーカーの探索(自012-0136終了）

  • がん微小環境における免疫細胞の役割（自014-0274）

  • 悪性胸膜中皮腫の前方視的データベース研究（自016-0413）

  • ヒト肺腫瘍における分子標的治療の効果予測因子と新規分子標的の探索研究（自012-0413）

  • 本邦における肺切除術後脳梗塞に関する周術期、手術因子の解析： 多施設共同研究（自014-0410）

  • 高齢者肺癌に対する外科治療の安全性と有効性を評価するための多施設共同前向き調査研究（自015-0129）

  • 非小細胞肺癌手術適応症例に対する周術期hANP 投与の多施設共同ランダム化第Ⅱ相比較試験（自015-0217）

  • 腫瘍血管内皮細胞による血管新生阻害物質のスクリーニング（自015-0460）

  • 非小細胞肺癌完全切除症例に対する周術期hANP投与の多施設共同ランダム化第II相比較試験における遺伝子解析（自015-0460）

  • 全国肺癌登録調査：2010年肺癌手術症例に対する登録研究（自015-0461）

  • 間質性肺炎合併肺癌切除患者における術後急性増悪予測 リスクスコアバリデーションスタディ－多施設共同非介入前向き研究－（自016-0223）

  • 肺癌に対するサルベージ手術の有効性と安全性を検討する多施設共同後ろ向き臨床研究（自017-0430）

  • ナノ粒子を用いた胸部悪性疾患に対する新規光線力学的療法（Photodynamic Therapy(PDT)）の開発

  • 新規ドラッグデリバリーシステムを用いた新たな胸腔鏡画像支援システムの開発

  • インドシアニングリーンおよび近赤外線胸腔鏡を用いた手術支援ナビゲーションに関する研究

  • 呼吸器外科手術および肺移植手術における手術手技研究

  • 小児胸腔鏡手術に関する研究

研究成果を内外に向けて論文発表をしています。

• Shiiya H, Hida Y, Kaga K, Inoue R, Nakada-Kubota R, Matsui Y. Extrapleural pneumonectomy of recurrent thymoma with pleural dissemination. Respirology case reports. 2018;6(4):e00308.pdf

• Shiina N, Kaga K, Hida Y, Sasaki T, Hirano S, Matsui Y. Variations of pulmonary vein drainage critical for lung resection assessed by three-dimensional computed tomography angiography. Thoracic cancer. 2018.pdf

• Miyasaka M, Noji T, Ohtaka K, Chiba R, Sato S, Shoji Y, et al. Long-term survival after repeated resection of metachronous lung metastases from pStage IA pancreatic adenocarcinoma. Clinical journal of gastroenterology. 2018;11(1):53-61.

• Kato T, Lee D, Huang H, Cruz W, Ujiie H, Fujino K, et al. Personalized siRNA-Nanoparticle Systemic Therapy using Metastatic Lymph Node Specimens Obtained with EBUS-TBNA in Lung Cancer. Molecular cancer research : MCR. 2018;16(1):47-57.

• Wada A, Kohno M, Oiwa K, Hashimoto R, Koizumi T, Nakamura Y, et al. Temporal Changes of Inflammatory Cytokine Profiles in Epithelial Lining Fluid in a Canine Lung Transplant Model. The Tokai journal of experimental and clinical medicine. 2017;42(4):165-75.pdf

• Ujiie H, Kato T, Lee D, Hu HP, Fujino K, Kaji M, et al. Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer. Int J Oncol. 2017;50(6):2154-70.

• Ujiie H, Kato T, Hu HP, Patel P, Wada H, Fujino K, et al. A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: A phase I feasibility trial. The Journal of thoracic and cardiovascular surgery. 2017;154(2):702-11.

• Ujiie H, Kato T, Hu HP, Hasan S, Patel P, Wada H, et al. Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs. The Annals of thoracic surgery. 2017;103(3):926-34.

• Ujiie H, Kato T, Hu HP, Bauer P, Patel P, Wada H, et al. Development of a novel ex vivo porcine laparoscopic Heller myotomy and Nissen fundoplication training model (Toronto lap-Nissen simulator). Journal of thoracic disease. 2017;9(6):1517-24.

• Torii C, Hida Y, Shindoh M, Akiyama K, Ohga N, Maishi N, et al. Vasohibin-1 as a Novel Prognostic Factor for Head and Neck Squamous Cell Carcinoma. Anticancer research. 2017;37(3):1219-25.

• Patel P, Wada H, Hu HP, Hirohashi K, Kato T, Ujiie H, et al. First Evaluation of the New Thin Convex Probe Endobronchial Ultrasound Scope: A Human Ex Vivo Lung Study. The Annals of thoracic surgery. 2017;103(4):1158-64.

• Maki T, Ikeda H, Kuroda A, Kyogoku N, Yamamura Y, Tabata Y, et al. Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification. Int J Oncol. 2017;50(1):129-40.

• Kato T, Jin CS, Ujiie H, Lee D, Fujino K, Wada H, et al. Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer. Lung cancer. 2017;113:59-68.

• Hojo T, Maishi N, Towfik AM, Akiyama K, Ohga N, Shindoh M, et al. ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells. Oncotarget. 2017;8(28):45484-95.

• Hida K, Maishi N, Akiyama K, Ohmura-Kakutani H, Torii C, Ohga N, et al. Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance. Cancer science. 2017;108(11):2195-203.

• Hida K, Kikuchi H, Maishi N, Hida Y. ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapy. Cancer letters. 2017;400:305-10.

• Hida K, Kawamoto T, Maishi N, Morimoto M, Akiyama K, Ohga N, et al. miR-145 promoted anoikis resistance in tumor endothelial cells. Journal of biochemistry. 2017;162(2):81-4.

• Aragaki M, Iimura Y, Yoshida Y, Hasegawa N. Anomalous V(2) of the left pulmonary vein detected using three-dimensional computed tomography in a patient with lung cancer: A case report. International journal of surgery case reports. 2017;37:208-10.

• Oiwa K, Kohno M, Hashimoto R, Nakagawa T, Masuda R, Nishiumi N, et al. Serial Epithelial Lining Fluid Collection Using Bronchoscopic Microsampling in a Canine Lung Transplantation Model. The Tokai journal of experimental and clinical medicine. 2016;41(4):218-26.pdf

• Ohtaka K, Hase R, Chiba R, Miyasaka M, Sato S, Shoji Y, et al. Noninvasive management for iatrogenic splenic injury caused by chest tube insertion: a case report. Clin Case Rep. 2016;4(12):1157-60.

• Naka T, Hatanaka Y, Marukawa K, Okada H, Hatanaka KC, Sakakibara-Konishi J, et al. Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma. Diagn Pathol. 2016;11:38.

• Kato T, Wada H, Patel P, Hu HP, Lee D, Ujiie H, et al. Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients. Lung cancer. 2016;92:53-61.

• Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, et al. SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 2016;49(6):2411-20.

• Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, et al. Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 2016;49(2):448-56.

• Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, et al. Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells. Cancer Res. 2016;76(20):6030-42.

• Yasuaki Iimura NH, Masato Aragaki, Kichizo Kaga. Thoracoscopic surgery using near infrared spectroscopy for ectopic parathyroid

• adenoma detected with gestational hypertension: A case report. The Japanese Association for Chest Surgery (JACS). 2015.

• Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, et al. Expression of fucosyltransferase 8 is associated with an unfavorable clinical outcome in non-small cell lung cancers. Oncology. 2015;88(5):298-308.

• Domen H, Kaga K, Hida Y, Honma N, Kubota R, Yagi Y, et al. [Investigation of lung cancer patients with cardiovascular disease]. Kyobu geka The Japanese journal of thoracic surgery. 2015;68(4):266-70.

• Aragaki M, Iimura Y, Hasegawa N, Kaga K. [Mediastinal Mature Teratoma Necessitating Resection of Superior Vena Cava]. Kyobu geka The Japanese journal of thoracic surgery. 2015;68(10):845-9.

• Xin Y, Hida Y, Kaga K, Iimura Y, Shiina N, Ohtaka K, et al. Left lobectomy might be a risk factor for atrial fibrillation following pulmonary lobectomy. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2014;45(2):247-50.

• Ohtaka K, Takahashi Y, Uemura S, Shoji Y, Hayama S, Ichimura T, et al. Blood stasis may cause thrombosis in the left superior pulmonary vein stump after left upper lobectomy. Journal of cardiothoracic surgery. 2014;9(1):159.

• Video-assisted thoracoscopic surgery using mobile computed tomography: new method for locating of small lung nodules, 9 Journal of cardiothoracic surgery(2014).

• Ohtaka K, Hida Y, Kaga K, Takahashi Y, Kawase H, Hayama S, et al. Left upper lobectomy can be a risk factor for thrombosis in the pulmonary vein stump. Journal of cardiothoracic surgery. 2014;9:5.

• Muto J, Hida Y, Kaga K, Ohtaka K, Okamoto S, Tamaki N, et al. Use of maximum standardized uptake value on fluorodeoxyglucose positron-emission tomography in predicting lymph node involvement in patients with primary non-small cell lung cancer. Anticancer research. 2014;34(2):805-10.

• Ohtaka K, Hida Y, Kaga K, Okamoto S, Shiga T, Tamaki N, et al. Outcome analysis of (18)F-fluorodeoxyglucose positron-emission tomography in patients with lung cancer after partial volume correction. Anticancer research. 2013;33(11):5193-8.

• Ohtaka K, Hida Y, Kaga K, Kato T, Muto J, Nakada-Kubota R, et al. Thrombosis in the pulmonary vein stump after left upper lobectomy as a possible cause of cerebral infarction. The Annals of thoracic surgery. 2013;95(6):1924-8.

• Ohtaka K, Hida Y, Kaga K, Kato T, Muto J, Nakada-Kubota R, et al. Limited resection and two-staged lobectomy for non-small cell lung cancer with ground-glass opacity. Journal of cardiothoracic surgery. 2013;8:111.

• Kaga K, Hida Y, Nakada-Kubota R, Ohtaka K, Muto J, Ishikawa K, et al. Reduced port video-assisted thoracoscopic surgery using a needle scope for lung and mediastinal lesions. Interactive cardiovascular and thoracic surgery. 2013;17(2):268-72.

• Ishikawa K, Miyamoto M, Yoshioka T, Kadoya M, Li L, Mishra R, et al. Method for the validation of immunohistochemical staining using SCID mouse xenografts: expression of CD40 and CD154 in human non-small cell lung cancer. Oncology reports. 2013;29(4):1315-21.

• Domen H, Hida Y, Okamoto S, Hatanaka KC, Hatanaka Y, Kaga K, et al. Histopathologic characterization of lung adenocarcinoma in relation to fluorine-18-fluorodeoxyglucose uptake on positron emission tomography. Japanese journal of clinical oncology. 2013;43(9):874-82.

• Betsuyaku T, Fuke S, Inomata T, Kaga K, Morikawa T, Odajima N, et al. Bronchiolar epithelial catalase is diminished in smokers with mild COPD. The European respiratory journal. 2013;42(1):42-53.

研究成果を内外に向けて学会や研究会で発表をしています。

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